Clinical Trial Services
Sinochips Diagnosis performs a comprehensive array of genomics-based assays to support all phases of drug development.
Multiplex PCR/RT-PCR based assays
Nucleic acid- based therapeutic evaluation
SNP genotying
Gene expression studies
mRNA profiling
Biomarker assessment
Assay feasibility, development, and validation
Biological sample analysis
FDA-EUA consultation
DNA/RNA extraction
ELISA assays
ADME
Next-Generation Sequencing
Current Clinical Trials
Cancer therapy and Immunogenicity of COVID Vaccine (CANINE Trial, IIT-2021-CANINE)
This is a trial of prospective collection of serial blood samples after administration of COVID-19 vaccine in patients with cancer who are receiving active cancer treatment, planned to start therapy with 14 days of consent, or have had stem cell transplant. Cancer treatments and administration of vaccine are not controlled by the study.
RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 Testing
This study proposes to examine the effectiveness of a Learning Collaborative’s effort that helps local community organizations address disparities in COVID-19 testing by building “Local Health Equity Action Teams” in 10 disproportionally COVID-19-affected counties.
A Trial of Aclaris Therapeutics, Inc. (ATI)-450 in Patients With Moderate-severe Novel Coronavirus Disease 2019 (COVID-19)
COVID-19 morbidity and mortality has been associated with Cytokine Release Syndrome (CRS) and Acute Respiratory Distress Syndrome (ARDS). ATI-450 is an oral small molecule MAPKAPK2 (MK2) inhibitor that potently inhibits multiple inflammatory cytokines. The investigator hypothesizes that MK2 pathway blockade during active COVID-19 infection in hospitalized participants will result in improvement in respiratory-failure free survival.
Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
HMG-CoA reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise). Individuals have genetic variations in proteins that metabolize/transport statins. We hypothesize that these variations modulate the relationship between statin use and lack of benefit from exercise. We will test this by having statin-users do supervised exercise for 6 weeks, measuring the cardiorespiratory fitness before/after and correlating this to genetic variations present in the patient.
Completed Research Projects
A prospective testing SARS-Cov-2/COVID-19 in cancer patients with antitumor treatment (DOI: 10.1158/1557-3265.COVID-19-PO-043 Published September 2020)
Preliminary analysis of factors associated with COVID-19-related disease severity in cancer patients: University of Kansas Cancer Center experience (DOI: 10.1158/1557-3265.COVID-19-PO-082 Published September 2020)
Prospective voluntary SARS-CoV-2 virus and anti-COVID-19 antibody tests in asymptomatic medical and research staff who work in direct contact with cancer patients: A single center study (DOI: 10.1158/1557-3265.COVID-19-21-P13 Published March 2021)
